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Contents
SECTION I Essential Renal Anatomy and
Physiology
1 Renal Anatomy, 1
Wilhelm Kriz, Marlies Elger
2 Renal Physiology
13
Matthew A. Bailey, Robert J. Unwin
SECTION II Investigation of Renal Disease
3 Assessment of Glomerular Filtration Rate, 27
Lesley A. Inker, Andrew S. Levey
4 Urinalysis, 37
David Navarro, Nuno Moreira Fonseca, Giuseppe Garigali, Giovanni
B. Fogazzi
5 Point of Care Ultrasound in Nephrology, 51
William Beaubien-Souligny, Abhilash Koratala
6 Radiologic and Nuclear Imaging in Nephrology, 68
David T.G. Wymer, David C. Wymer
7 Kidney Biopsy, 86
Peter S. Topham, Rob MacGinley
SECTION III Fluid and Electrolyte Disorders
8 Disorders of Extracellular Volume, 94
David H. Ellison
9 Disorders of Water Metabolism, 108
Ali Kashkouli, Tomas Berl, Jeff M. Sands
10 Disorders of Potassium Metabolism, 125
I. David Weiner, Stuart L. Linas, Charles S. Wingo
11 Disorders of Calcium, Phosphate, and Magnesium
Metabolism, 137
Bryan Kestenbaum, Pascal Houillier
12 Normal Acid-Base Balance, 154
Biff F. Palmer
13 Metabolic Acidosis, 161
Biff F. Palmer
14 Metabolic Alkalosis, 172
Harold M. Szerlip, Michael Emmett
15 Respiratory Acidosis, Respiratory Alkalosis, and Mixed
Acid-Base Disorders, 182
Anip Bansal
SECTION IV Glomerular Disease
16 Introduction to Glomerular Disease: Clinical
Presentations, 193
Jürgen Floege, Richard J. Johnson
17 Introduction to Glomerular Disease: Histologic
Classication and Pathogenesis, 207
Jürgen Floege, Peter Boor
18 Minimal Change Disease, 217
Charlotte Seneschall, Gabriel Cara Fuentes, Megan Grifth
19 Primary and Secondary (Nongenetic) Causes of Focal
and Segmental Glomerulosclerosis, 226
Dominick Santoriello, Jai Radhakrishnan
20 Inherited Causes of Nephrotic Syndrome, 237
Ronen Schneider, Friedhelm Hildebrandt
21 Membranous Nephropathy, 245
David J. Salant, Laurence H. Beck Jr, Heather N. Reich
22 Immunoglobulin-Mediated Glomerulonephritis
With a Membranoproliferative Pattern of Injury and
Cryoglobulinemic Glomerulonephritis, 259
Sanjeev Sethi, An S. De Vriese, Fernando C. Fervenza
23 Glomerulonephritis Associated With Complement
Disorders, 268
Joshua M. Thurman, H. Terence Cook, Matthew C. Pickering
24 Immunoglobulin A Nephropathy and Immunoglobulin A
Vasculitis (Henoch-Schönlein Purpura), 274
Jürgen Floege, Jonathan Barratt, Hong Zhang
25 Anti–Glomerular Basement Membrane Disease and
Goodpasture Disease, 285
Richard G. Phelps, A. Neil Turner
26 Renal and Systemic Vasculitis, 294
Meghan Free, J. Charles Jennette, Ronald J. Falk, Koyal Jain
27 Lupus Nephritis, 309
Ana Malvar, Valeria Alberton, Brad H. Rovin
28 Monoclonal Immunoglobulin–Related Glomerular
Diseases and Renal Amyloidosis, 323
Frank Bridoux, Jean-Paul Fermand, Nelson Leung, Pierre Ronco, Guy
Touchard
29 Rare Glomerular Disorders, 337
Cynthia C. Nast, Sharon G. Adler, Richard J. Glassock
30 Thrombotic Microangiopathies, Including Hemolytic
Uremic Syndrome, 350
Marina Noris, Piero L. Ruggenenti, Giuseppe Remuzzi
SECTION V Diabetic Kidney Disease
31 Pathogenesis, Clinical Manifestations, and Natural
History of Diabetic Kidney Disease, 363
Sydney C.W. Tang, Kumar Sharma
32 Prevention and Treatment of Diabetic Kidney Disease, 380
Li-Li Tong, Sharon Adler, Christoph Wanner
33 Management of Patients With Diabetes and Chronic
Kidney Disease, 389
Vikas S. Sridhar, Christine P. Limonte, David Z.I. Cherney,
Ian H. de Boe
SECTION VI Hypertension
34 Normal Blood Pressure Control and the Evaluation of
Hypertension, 403
William J. Elliott
35 Primary Hypertension, 419
Bernardo Rodríguez-Iturbe, George L. Bakris, Richard J. Johnson
36 Nonpharmacologic Prevention and Treatment of
Hypertension, 428
Brian Rayner, Karen E. Charlton, Wayne Derman, Erika Jones
37 Pharmacologic Treatment of Hypertension, 436
Bryan Williams
38 Evaluation and Treatment of Hypertensive Urgencies
and Emergencies, 451
Pantelis A. Saradis, George L. Bakris
39 Endocrine Causes of Hypertension: Aldosterone, 460
I. David Weiner, Charles S. Wingo
40 Other Endocrine Causes of Hypertension, 471
A. Lauren Fishbein, Mark Richards, Debbie L. Cohen
41 Neurogenic Hypertension, Including Hypertension
Associated With Stroke or Spinal Cord Injury, 483
Venkatesh Aiyagari, Philip B. Gorelick
42 Blood Pressure Management in the Dialysis Patient, 492
Panagiotis I. Georgianos, Rajiv Agarwa
Introduction
The seventh edition of Comprehensive Clinical Nephrology remains the
textbook aimed for Fellows preparing for their boards, for practicing
nephrologists who want to rapidly review the key aspects for diagnosis
and management of their patients, and for a short updated review for
both the novice and expert alike on the pathogenesis and treatment
of kidney diseases. As always, this remains a single-volume textbook
that provides comprehensive coverage of clinical nephrology yet also
ensures that inquiring nephrologists can nd the key scientic issues
and pathophysiology that underlie their clinical work.
The seventh edition boasts updated chapters providing state-ofthe-art recommendations for the diagnosis and management of kidney diseases.
This includes a new chapter on ultrasound use from a
nephrologist’s perspective. Other highlights include chapters on geriatric nephrology and palliative nephrology, the mysterious epidemics
of CKD that have been identied in various regions of the world, and
continued emphasis on ICU nephrology.
By popular demand, we continue to offer readers digital access to
the images from the book, and each chapter also includes a larger number of references available online as well as the answers to the multiplechoice questions in each chapter. This is also the fourth edition to
feature access to a companion eBooks+ website with fully searchable
text, a downloadable image library, and links to PubMed.
Enjoy the new updated book, and feel free to give us suggestions for
the next editions
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