Download The Only MRCP Notes You Will Ever Need 4th Edition 2024 pdf Easily In Format For Free
PREFACE
These notes intended to target those who are appearing in MRCP exam. The idea behind it was
collecting the most commonly tested topics and facts in the exam for my personal revision. The data
has been collected from many sources.
This book was not prepared to be the primary studying source but it can help you after finishing your
primary reading by arranging the thoughts in your mind and making every topic as short as possible by
highlighting the most important points about it. You may use it just before going through your favorite
MCQs book or internet site.
A friend of mine appeared in part one for couple of times, he reached to a conclusion and gave me a
valuable advice that said ‘when preparing for MRCP, study MRCP! Don’t study medicine!’ this book
helps you to study MRCP rather than studying medicine. But at the end, you have to be a good
physician otherwise MRCP will be a less valuable recognition, this is why I would advise to study
medicine before you study MRCP and for sure before you say that you are a member of the Royal
College you have to be upto the expectations.
This edition contains the latest guidelines including 2011 guidelines and recommendations. It is more
organized than ever.
In the 4th edition we have added topics that matters for part two, we have added many pictures, we
claim that it’s just enough to get you through the second part comfortably.
Kallman Syndrome
is a recognised cause of delayed puberty secondary to hypogonadotrophic
hypogonadism. It is usually inherited as an X-linked recessive trait. Kallman's syndrome is thought to
be caused by failure of GnRH-secreting neurons to migrate to the hypothalamus. The clue given in
many questions is lack of
smell (anosmia) in a boy with delayed puberty
Features
Delayed puberty
Hypogonadism,
cryptorchidism (including undescended tests)
Anosmia
Sex hormone levels are low
LH, FSH levels are inappropriately low/normal
Patients are typically of normal or above average height
Cleft lip/palate and visual/hearing defects are also seen in some patients
Noonan Syndrome
Often thought of as the '♂ Turner's', Noonan's syndrome is an autosomal
dominant condition associated with a normal karyotype. It is thought to be caused by a defect in a gene
on chromosome 12. As well as features similar to Turner's syndrome (webbed neck, widely-spaced
nipples, short stature, pectus carinatum and excavatum), a number of characteristic clinical signs may
also be seen
Cardiac: pulmonary valve stenosis
• Ptosis
• Triangular-shaped face
• Low-set ears
• Coagulation problems: factor XI deficiency
Patau Syndrome
also known as trisomy 13 and trisomy D, is a chromosomal abnormality, a
syndrome in which a patient has an additional chromosome 13 due to a non-disjunction of
chromosomes during meiosis. Some are caused by Robertsonian translocations. The extra chromosome
13 disrupts the normal course of development, causing the characteristic features of Patau syndrome.
Like all non-disjunction conditions (Down syndrome, Edwards syndrome, etc.), the risk of this
syndrome in the offspring ↑ with maternal age at pregnancy, with about 31 years being the average.
Patau syndrome affects approximately 1 in 25,000 live births.
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