outcomes, nurses must have advanced knowledge from many different areas, but particularly in the content domains of physiology/pathophysiology, physical assessment,
and pharmacology. For advanced practice nurses in direct care roles (i.e., certified registered nurse anesthetist [CRNA], certified nurse-midwife [CNM], clinical nurse specialist
[CNS], or certified nurse practitioner [CNP]), it is especially critical (and mandated by
some accrediting bodies) that students are prepared by separate classes in each of
these content areas (American Association of Colleges of Nursing [AACN], 2011).
There are requirements for a clinical component for direct care roles, which can be
met in traditional settings or through simulation (e.g., educators, clinical nurse leader
[CNL]) (Halstead, 2007, 2018; National League for Nursing [NLN], 2012). In addition to the advanced knowledge, the nurse must integrate these concepts to function
safely across inpatient and community-based health-care settings. For graduate students in tracks that lead to indirect care roles (e.g., administration, informatics), these
concepts can be combined into one class (AACN, 2011; American Nurses Association
[ANA], 2015).
Recommendations for graduate education are based in part on the Carnegie Foundation report (2009), Educating Nurses: A Call for Radical Transformation, which emphasizes the importance of advancing knowledge for masters-prepared nurses in clinical
practice theory and experience for all direct care roles (Benner, Sutphen, Leonard, &
Day, 2009). A scientific foundation for practice is formed from the three major areas
(physiology/pathophysiology, physical assessment, and pharmacology) with opportunities to apply this knowledge in clinical settings, whether in traditional clinical or
simulated settings. In this chapter, we provide an overview of how each of these subjects supports advanced practice in nursing and how their integration promotes patient
and system outcomes
Physiology/Pathophysiology
Nursing education includes physiology at the undergraduate level but often moves to
a focus on pathophysiology for graduate students, with the expectation that students
possess basic knowledge of physiology from nursing practice experience. It is also
assumed that students and/or practicing nurses review physiology content as needed in
order to better understand pathophysiology. Within a wide variety of health-care settings, nurses must be able to determine normal findings based on their understanding
of physiology, and identify any deviations from normal findings, or pathophysiology.
While nursing is based in science, there is also a human element that requires nurses to
make judgments using both scientific knowledge of pathophysiology and understanding of best practices; therefore, as nurses progress in their educational preparation for
advanced roles, an emphasis on scientific knowledge, along with clinical application of
this information, is necessary (Rodgers, 2016).
Advanced Physical Assessment
While based on the sciences, nursing is described as both a science and an art; nowhere
is this more evident than in the area of physical assessment. Learned as the first step
in the nursing process, accurate assessment is crucial to all other components of care;
students and practicing nurses cannot underestimate its importance. As the nurse
develops knowledge in caring for patients, there are usually concomitant advances in
clinical skills. Advanced assessment skills incorporate both physical assessment and
clinical reasoning skills that support the nurse’s ability to correlate assessment findings
with possible diagnoses and treatment plans (Goolsby & Grubbs, 2019). The nurse’s
ability to assess a patient and their family is critical to making correct decisions regarding care. Expectations of masters-prepared nurses include expertise with advanced
assessment skills; while there is a focus on the aspect of physical assessment, a holistic
approach to assessment is the ultimate goal.
Pharmacology
Knowledge of medication and its safe use/administration is a priority in current
health care. The landmark Institute of Medicine (IOM; now the National Academy
of Medicine) report, To Err Is Human (1999), continues to guide clinical practice and
motivate nurses to promote a safe clinical environment. Pharmacology has a vital role
across the continuum of care; nurses must be able to manage its use in treating acute
illness, managing chronic conditions, and preventing disease. It is the nurse’s role to
maximize the therapeutic effects of the pharmacological regimen, while minimizing
the potential side effects and risk of complications. Nurses’ advanced knowledge of
pharmacology is key to their ability to practice in an advanced role and to be leaders
in promoting quality care.
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