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Molecular oncologic pathology is one of the most dynamic fields of medicine and has become an integral part of the field of pathology in particular. Introduction of massively parallel sequencing technology (a.k.a. next-generation sequencing) in recent years resulted in discovery of several clinically actionable somatic mutations in solid tumors and in hematologic malignancies. These discoveries have refined our understanding of molecular pathogenesis of human diseases in general, and have led to the discovery of many new molecular targeted therapies, particularly in human cancers. Several of the recently discovered molecular genetic findings have already become critical for the diagnosis of distinct disease entities and key to personalized medicine. In oncologic pathology, these advancements have dramatically changed the role of the purely morphologic- and immunophenotypic-based pathologist to that of a consultant who incorporates molecular genetic results into the pathology report. In fact, pathologists now comprehensively interpret molecular data and create integrated reports with inclusion of the most clinically useful data in diagnostic line with references to FDA-approved or off-label targeted therapy, such as kinase inhibitors, that would be efficacious in a given tumor. Understanding new molecular information can be difficult for pathologists, clinicians, residents, and medical students. This book is intended to serve as a guide for practicing pathologists and pathology residents and fellows to keep up with the rapidly evolving practice of pathology in an era of personalized medicine. The 2nd edition of Diagnostic Pathology: Molecular Oncology is a detailed, richly illustrated reference covering molecular tests and their clinical applications, along with organ-based chapters on the molecular genetic data relevant to individual disease entities. Focusing on accurate interpretation and diagnosis, as well as appropriate molecular testing, allows the creation of integrated reports that would guide oncologists in making proper treatment decisions. There is a scarcity of molecular pathology textbooks that are comprehensive but easy to understand. Traditional textbooks are commonly paragraph based with few photographs. In contrast, this book is extensively illustrated and written in a concise bulleted format, allowing the reader to easily find relevant information. The information covered in the text is cutting edge. Knowledge of the rapidly growing body of information regarding molecular pathology is essential to the understanding of modern-day medicine. We hope that this textbook will be a valuable guide for this purpose. No book in the molecular genetic pathology can be considered complete given the dynamic nature of the field. Therefore, we invite the readers to share their thoughts, and we appreciate any feedback.
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