Pathophysiology of Disease: An Introduction to Clinical Medicine
Preface
Goal and Audience
The goal of Pathophysiology of Disease: An Introduction to Clinical Medicine,
as outlined in the introductory chapter (Chapter 1), is to introduce students to
clinical medicine by reviewing the pathophysiologic basis of the symptoms and
signs of various common diseases
.
The book has proved useful as a text for both Pathophysiology and
Introduction to Clinical Medicine courses in medical schools, and it has been
popular in similar courses in nursing schools, physician assistants’ training
programs, and other allied health programs
. It is valuable to students early in
their medical school years by highlighting the clinical relevance of their basic
science courses, and in preparation for their USMLE Step 1 examinations
. The
book is also helpful to students engaged in their internal medicine and surgery
clerkships, and to house officers as an up-to-date summary of relevant
physiology and a source of key references
. Practitioners (both general internists
and specialists who provide generalist care) will find it beneficial as a refresher
text, designed to update their knowledge of the mechanisms underlying 132
commonly encountered diseases and disorders. Nurses, nurse-practitioners,
physician assistants, and other allied health practitioners have found that its
concise format and broad scope facilitate their understanding of these basic
disease entities.
Pathophysiology of Disease has been widely adopted in the United States,
Canada, and the United Kingdom, and it has been translated into Spanish,
Italian, Chinese, Japanese, Greek, and Turkish
. Both the text and its Case Study
Questions and Answers are also available online at
accessmedicine.mhmedical.com, the online version of McGraw-Hill’s many
medical textbooks (search under “Books, Library, Basic Science” for
“Pathophysiology,” listed alphabetically).
New Features for This Edition
In preparation for this eighth edition, the editors and authors reviewed the entire
book
. There have been many text revisions aimed at updating information,
improving clarity, and eliminating minor errors. With emphasis on recent
pertinent reviews, references have been entirely updated, as have figures and
tables. “Checkpoints,” collections of review questions, continue to appear
throughout the chapters and have been revised.
Examples of Substantive New Content Found in This Eighth
Edition
• Update on components and physiology of normal immunity
• Most recent surveillance case definition for HIV infection
• Explication of the concepts of innate immunity and pathogen-associated
molecular patterns
• Totally revised chapter on neoplasia, including 19 new figures and 4 new
tables
• New figure illustrating iron transport and regulation in the duodenal
enterocyte
• New chapter section on urticaria (perivascular dermatitis)
• New chapter section on various forms of spinocerebellar ataxia
• Clarification in text and figures of regional alterations in the overall
distribution of ventilation and perfusion referred to as mismatch,
including concepts of anatomic versus alveolar (wasted ventilation) dead
space and right-to-left shunt
• Update on genetic factors implicated in asthma risk, as well as allergic versus
nonallergic asthma
• Newly rewritten section on idiopathic pulmonary fibrosis as a prototypic
restrictive (interstitial) lung disease
• Extensive revision of sections on pulmonary edema, adult respiratory distress
syndrome (ARDS), and pulmonary venous thromboembolism
• Expanded material on paragangliomas
• New figures on mechanisms leading to nonalcoholic fatty liver disease and to
hepatic steatosis
• New table summarizing adverse prognostic signs in acute pancreatitis derived
from the Acute Pancreatitis Classification Working Group’s 2012
classification, a revision of the Atlanta international consensus classification
and definitions of acute pancreatitis
• New table summarizing genetic syndromes associated with . .pancreatic cancer
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