Braunwald's Heart Disease 11th Edition
Preface
This is the 11th edition of the classic textbook, Heart Disease: A Textbook Of Cardiovascular Medicine,
that Dr
. Eugene Braunwald began almost 40 years ago. The editors are pleased and honored to dedicate
this edition to him for his extraordinary contributions to the discipline of cardiology, especially this
textbook and its companions, and for his unique concept of creating a “living textbook.”
In the past several decades, cardiology has advanced at a breakneck pace on many fronts. Knowledge
of the diagnosis and management of patients with heart disease, as well as understanding of responsible
mechanisms and preventive approaches, advance daily
. Genetics, molecular biology and pharmacology,
imaging, catheter-based therapy, and cardiac repair are only a sampling of what we encounter daily
.
This constant flow of innovative research has generated a proliferation of new cardiovascular journals,
cumulatively publishing an unprecedented amount of information
. With the rapidly changing
cardiovascular knowledge base, an authoritative textbook like Heart Disease to which readers can turn,
confident that the statements are as accurate and up-to-date as possible, offers even greater value
.
As with each edition of this reference work, international experts — household names to many readers
— have totally revised every chapter. In addition, 14 new chapters have been added to recognize the
ever-expanding role of cardiology into areas such as oncology, chronic lung disease, environmental
toxins, catheter-based treatments of congenital heart disease, and other topics
. Some sections have been
revised for clarity, such as arrhythmias; some have been expanded, such as diseases of heart valves;
others have had a shift of emphasis, such as congenital heart disease in the adult. Finally, to maintain
vitality of standard topics, new authors have replaced more than a third of those who have tirelessly
written for previous editions, in chapters on ethics, personalized and precision medicine, imaging,
obesity, diabetes, sleep-disordered breathing, autonomic nervous system, and other areas.
In the preface for the 10th edition of Heart Disease, we emphasized that the online version contained
audio, video, and written information not available in the print edition
. We have continued and expanded
this practice. To put this 11th edition in perspective, it contains more than 2700 illustrations and 565
tables, while maintaining the number of printed pages near 2000
. The eBook includes an additional 400
illustrations, 60 tables, and 300 .videos
Global Burden of Cardiovascular Disease
Over the last decade, cardiovascular disease (CVD) has become the leading cause of death worldwide
. In
2013, CVD caused an estimated 17.3 million deaths and led to 330 million disability-adjusted life-years
(DALYs) lost
1—about 32% of all deaths and 13% of all DALYs lost that year
. Overall, these data
represent increases in both absolute numbers and percentages of deaths and DALYs compared with 2010
estimates
. As with many high-income countries during the last century, low- and middle-income countries
are now experiencing an alarming and accelerating increase in CVD
.
This chapter reviews the features of the epidemiologic transitions underlying this shift in CVD
morbidity and mortality and evaluates the transition in different regions of the world
. A survey of the
current burden of risk factors and behaviors associated with CVD includes regional variations and trends.
A review of the economic impact of CVD highlights the cost-effectiveness of various strategies to reduce
it
. The chapter ends with a discussion of the diverse challenges that the increasing burden of CVD poses
for various regions of the world, along with potential solutions to this global problem.
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